A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation

MicroRNAs (miRNAs) have been implicated in DNA repair pathways through transcriptional responses to DNA damaging agents or through predicted miRNA regulation of DNA repair genes. We hypothesized that additional DNA damage regulating miRNAs could be identified by screening a library of 810 miRNA mime...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Hatano, Koji, Kumar, Binod, Zhang, Yonggang, Coulter, Jonathan B., Hedayati, Mohammad, Mears, Brian, Ni, Xiaohua, Kudrolli, Tarana A., Chowdhury, Wasim H., Rodriguez, Ronald, DeWeese, Theodore L., Lupold, Shawn E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417178/
https://ncbi.nlm.nih.gov/pubmed/25845598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv273
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