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Bicalutamide Activated Oncolytic Adenovirus for the Adjuvant Therapy of High Risk Prostate Cancer

Conditionally replicating adenoviruses (CRAds) utilize tissue specific promoters to control the expression of the early genes, E1A and E1B, to preferentially replicate and lyse tumor cells (oncolysis). Previous CRAds used in prostate cancer gene therapy require androgens to activate prostate specifi...

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Bibliografiske detaljer
Main Authors: Johnson, Tamara Jane, Hoti, Naser Uddin, Liu, Chunyan, Chowdhury, Wasim H., Li, Ying, Zhang, Yonggang, Lupold, Shawn E., DeWeese, Theodore, Rodriguez, Ronald
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732197/
https://ncbi.nlm.nih.gov/pubmed/23764901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2013.34
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