Aptamer-Mediated Codelivery of Doxorubicin and NF-κB Decoy Enhances Chemosensitivity of Pancreatic Tumor Cells

Aptamers able to bind efficiently cell-surface receptors differentially expressed in tumor and in healthy cells are emerging as powerful tools to perform targeted anticancer therapy. Here, we present a novel oligonucleotide chimera, composed by an RNA aptamer and a DNA decoy. Our assembly is able to...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Porciani, David, Tedeschi, Lorena, Marchetti, Laura, Citti, Lorenzo, Piazza, Vincenzo, Beltram, Fabio, Signore, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417125/
https://ncbi.nlm.nih.gov/pubmed/25919089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.9
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