Positive control mutations in the MyoD basic region fail to show cooperative DNA binding and transcriptional activation in vitro.
An in vitro transcription system from HeLa cells has been established in which MyoD and E47 proteins activate transcription both as homodimers and heterodimers. However, heterodimers activate transcription more efficiently than homodimers, and function synergistically from multiple binding sites. Po...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1994
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44170/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8016142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.13.6221 |
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