Zinc Inhibits Hedgehog Autoprocessing: LINKING ZINC DEFICIENCY WITH HEDGEHOG ACTIVATION

Zinc is an essential trace element with wide-ranging biological functions, whereas the Hedgehog (Hh) signaling pathway plays crucial roles in both development and disease. Here we show that there is a mechanistic link between zinc and Hh signaling. The upstream activator of Hh signaling, the Hh liga...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Xie, Jian, Owen, Timothy, Xia, Ke, Singh, Ajay Vikram, Tou, Emiley, Li, Lingyun, Arduini, Brigitte, Li, Hongmin, Wan, Leo Q., Callahan, Brian, Wang, Chunyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416862/
https://ncbi.nlm.nih.gov/pubmed/25787080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.623264
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