Compartmentalized Accumulation of cAMP near Complexes of Multidrug Resistance Protein 4 (MRP4) and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Contributes to Drug-induced Diarrhea

Diarrhea is one of the most common adverse side effects observed in ∼7% of individuals consuming Food and Drug Administration (FDA)-approved drugs. The mechanism of how these drugs alter fluid secretion in the gut and induce diarrhea is not clearly understood. Several drugs are either substrates or...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Moon, Changsuk, Zhang, Weiqiang, Ren, Aixia, Arora, Kavisha, Sinha, Chandrima, Yarlagadda, Sunitha, Woodrooffe, Koryse, Schuetz, John D., Valasani, Koteswara Rao, de Jonge, Hugo R., Shanmukhappa, Shiva Kumar, Shata, Mohamed Tarek M., Buddington, Randal K., Parthasarathi, Kaushik, Naren, Anjaparavanda P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416832/
https://ncbi.nlm.nih.gov/pubmed/25762723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.605410
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