Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice

ADAM10, as the sheddase of the low affinity IgE receptor (CD23), promotes IgE production and thus is a unique target for attenuating allergic disease. Herein, we describe that B cell levels of ADAM10, specifically, are increased in allergic patients and Th2 prone WT mouse strains (Balb/c and A/J). W...

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Publicat a:PLoS One
Autors principals: Cooley, Lauren Folgosa, Martin, Rebecca K., Zellner, Hannah B., Irani, Anne-Marie, Uram-Tuculescu, Cora, El Shikh, Mohey Eldin, Conrad, Daniel H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416757/
https://ncbi.nlm.nih.gov/pubmed/25933166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124331
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