ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

The proteolytic activity of a disintegrin and metalloproteinase 10 (ADAM10) regulates cell-fate decisions in Drosophila and mouse embryos. However, in utero lethality of ADAM10(−/−) mice has prevented examination of ADAM10 cleavage events in lymphocytes. To investigate their role in B cell developme...

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Autori principali: Gibb, David R., El Shikh, Mohey, Kang, Dae-Joong, Rowe, Warren J., El Sayed, Rania, Cichy, Joanna, Yagita, Hideo, Tew, John G., Dempsey, Peter J., Crawford, Howard C., Conrad, Daniel H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839139/
https://ncbi.nlm.nih.gov/pubmed/20156974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091990
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