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Blocking of Interferon Regulatory Factor 1 Reduces Tumor Necrosis Factor α–Induced Interleukin-18 Bioactivity in Rheumatoid Arthritis Synovial Fibroblasts by Induction of Interleukin-18 Binding Protein a: Role of the Nuclear Interferon Regulatory Factor 1–NF-κB–c-Jun Complex
OBJECTIVE: To examine the role of interferon regulatory factor 1 (IRF-1) in tumor necrosis factor α (TNFα)–induced interleukin-18 binding protein a (IL-18BPa) expression in rheumatoid arthritis synovial fibroblasts (RASFs). METHODS: TNFα-induced IRF-1 expression was assessed by real-time quantitativ...
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| Publicado no: | Arthritis Rheum |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4416229/ https://ncbi.nlm.nih.gov/pubmed/21834067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30583 |
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