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Blocking ERK1/2 reduces TNF-α-induced-IL-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of IL-18BPa Role of ERK1/2 in IL-18 bioactivity regulation
OBJECTIVE: To examine the mechanism of regulation of interleukin-18 (IL-18) bioactivity by IL-18 binding protein (IL-18BP) induction. METHODS: Levels of IL-18 and IL-18BPa expression were determined by enzyme-linked immunosorbent assays (ELISA) in osteoarthritis (OA) and rheumatoid arthritis (RA) sy...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2855552/ https://ncbi.nlm.nih.gov/pubmed/20131228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27269 |
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