Blocking the janus-activated kinase pathway reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity by caspase-1 inhibition

INTRODUCTION: Our objective was to examine the role of the janus-activated kinase (JAK) pathway in the modulation of tumor necrosis factor-α (TNF)-induced-IL-18 bioactivity by reduction of caspase-1 function. METHODS: Caspase-1 expression in rheumatoid arthritis (RA) synovial fibroblasts treated wit...

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Detalhes bibliográficos
Main Authors: Marotte, Hubert, Tsou, Pei-Suen, Fedorova, Tatiana, Pinney, Adam J, Lewis, Benjamin, Koch, Alisa E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060193/
https://ncbi.nlm.nih.gov/pubmed/24762050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4551
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