Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

[Image: see text] In recent years, the first generation of β-secretase (BACE1) inhibitors advanced into clinical development for the treatment of Alzheimer’s disease (AD). However, the alignment of drug-like properties and selectivity remains a major challenge. Herein, we describe the discovery of a...

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Publicado no:J Med Chem
Main Authors: Brodney, Michael A., Beck, Elizabeth M., Butler, Christopher R., Barreiro, Gabriela, Johnson, Eric F., Riddell, David, Parris, Kevin, Nolan, Charles E., Fan, Ying, Atchison, Kevin, Gonzales, Cathleen, Robshaw, Ashley E., Doran, Shawn D., Bundesmann, Mark W., Buzon, Leanne, Dutra, Jason, Henegar, Kevin, LaChapelle, Erik, Hou, Xinjun, Rogers, Bruce N., Pandit, Jayvardhan, Lira, Ricardo, Martinez-Alsina, Luis, Mikochik, Peter, Murray, John C., Ogilvie, Kevin, Price, Loren, Sakya, Subas M., Yu, Aijia, Zhang, Yong, O’Neill, Brian T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415909/
https://ncbi.nlm.nih.gov/pubmed/25781223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00191
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