SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage

Secreted protein, acidic and rich in cysteine (SPARC) is involved in many biological process including liver fibrogenesis, but its role in acute liver damage is unknown. To examine the role of SPARC in acute liver injury, we used SPARC knock-out (SPARC(−/−)) mice. Two models of acute liver damage we...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Peixoto, E, Atorrasagasti, C, Aquino, JB, Militello, R, Bayo, J, Fiore, E, Piccioni, F, Salvatierra, E, Alaniz, L, García, MG, Bataller, R, Corrales, F, Gidekel, M, Podhajcer, O, Colombo, MI, Mazzolini, G
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415270/
https://ncbi.nlm.nih.gov/pubmed/25410742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.102
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