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TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion

Glucose regulation of pancreatic α-cell Ca(2+) entry through voltage-dependent Ca(2+) channels is essential for normal glucagon secretion and becomes defective during the pathogenesis of diabetes mellitus. The 2-pore domain K(+) channel, TWIK-related acid-sensitive K(+) channel 1 (TASK-1), is an imp...

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Publicat a:Mol Endocrinol
Autors principals: Dadi, Prasanna K., Luo, Brooke, Vierra, Nicholas C., Jacobson, David A.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415209/
https://ncbi.nlm.nih.gov/pubmed/25849724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1321
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