The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

To investigate the role of enhancer of zeste homolog (EZH) 1 and EZH2 in liver homeostasis, mice were generated that carried Ezh1(−/−) and EZH2(fl/fl) alleles and an Alb-Cre transgene. Only the combined loss of EZH1 and EZH2 in mouse hepatocytes caused a depletion of global trimethylation on Lys 27...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Bae, Woo Kyun, Kang, Keunsoo, Yu, Ji Hoon, Yoo, Kyung Hyun, Factor, Valentina M., Kaji, Kosuke, Matter, Matthias, Thorgeirsson, Snorri, Hennighausen, Lothar
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2015
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415007/
https://ncbi.nlm.nih.gov/pubmed/25477280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-261537
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