The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers

Enhancer of zeste homolog 2 (EZH2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) and its demethylation is catalyzed by UTX. EZH2 levels are frequently elevated in breast cancer and have been proposed to control gene expression through regulating repressive H3K27me3 marks. However, it i...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Carcinog
Päätekijät: Bae, Woo Kyun, Yoo, Kyung Hyun, Lee, Ji Shin, Kim, Young, Chung, Ik-Joo, Park, Min Ho, Yoon, Jung Han, Furth, Priscilla A, Hennighausen, Lothar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286524/
https://ncbi.nlm.nih.gov/pubmed/25043748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22188
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