Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Here we inactivated all three catalytically active DNA methyltransferases in human embryonic stem cells (ESCs) using CRISPR/Cas9 genome editing to further investigate their role...

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發表在:Nat Genet
Main Authors: Liao, Jing, Karnik, Rahul, Gu, Hongcang, Ziller, Michael J., Clement, Kendell, Tsankov, Alexander M., Akopian, Veronika, Gifford, Casey A., Donaghey, Julie, Galonska, Christina, Pop, Ramona, Reyon, Deepak, Tsai, Shengdar Q., Mallard, William, Joung, J. Keith, Rinn, John L., Gnirke, Andreas, Meissner, Alexander
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414868/
https://ncbi.nlm.nih.gov/pubmed/25822089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3258
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