Metabolomic analysis reveals decreased skeletal muscle amino acid content and altered fatty acid handling in obese humans

OBJECTIVE: Investigate the effects of obesity and high fat diet (HFD) exposure on fatty acid oxidation and TCA cycle intermediates and amino acids in skeletal muscle to better characterize energy metabolism. DESIGN AND METHODS: Plasma and skeletal muscle metabolomic profiles were measured from lean...

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Библиографические подробности
Опубликовано в: :Obesity (Silver Spring)
Главные авторы: Baker, Peter R., Boyle, Kristen E., Koves, Timothy R., Ilkayeva, Olga R., Muoio, Deborah M., Houmard, Joseph A., Friedman, Jacob E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414721/
https://ncbi.nlm.nih.gov/pubmed/25864501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.21046
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