Peptides of Presenilin-1 Bind the Amyloid Precursor Protein Ectodomain and Offer a Novel and Specific Therapeutic Approach to Reduce ß-Amyloid in Alzheimer’s Disease

β-Amyloid (Aβ) accumulation in the brain is widely accepted to be critical to the development of Alzheimer’s disease (AD). Current efforts at reducing toxic Aβ40 or 42 have largely focused on modulating γ-secretase activity to produce shorter, less toxic Aβ, while attempting to spare other secretase...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Dewji, Nazneen N., Singer, S. Jonathan, Masliah, Eliezer, Rockenstein, Edward, Kim, Mihyun, Harber, Martha, Horwood, Taylor
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414571/
https://ncbi.nlm.nih.gov/pubmed/25923432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122451
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