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Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors
The β-lactam cholesterol absorption inhibitor ezetimibe is so far the only representative of this class of compounds on the market today. The goal of this work was to synthesize new amide ezetimibe analogs from trans-3-amino-(3R,4R)-β-lactam and to test their cytotoxicity and activity as cholesterol...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4414353/ https://ncbi.nlm.nih.gov/pubmed/25882530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.03.067 |
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