Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella

Prokaryotes protect their genomes from foreign DNA with a diversity of defense mechanisms, including a widespread restriction-modification (R-M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R-M systems, highly partial PT-modification of consensus motifs i...

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Detalhes bibliográficos
Publicado no:Mol Microbiol
Main Authors: Cao, Bo, Cheng, Qiuxiang, Gu, Chen, Yao, Fen, DeMott, Michael S., Zheng, Xiaoqing, Deng, Zixin, Dedon, Peter C., You, Delin
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414249/
https://ncbi.nlm.nih.gov/pubmed/25040300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12692
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