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Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability
Genomic modification with sulfur as phosphorothioate (PT) is widespread among prokaryotes, including human pathogens. Apart from its physiological functions, the redox and nucleophilic properties of PT sulfur suggest effects on bacterial fitness in stressful environments. Here we show that PTs are d...
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| Pubblicato in: | Nat Chem Biol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5577368/ https://ncbi.nlm.nih.gov/pubmed/28604692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2407 |
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