Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability

Genomic modification with sulfur as phosphorothioate (PT) is widespread among prokaryotes, including human pathogens. Apart from its physiological functions, the redox and nucleophilic properties of PT sulfur suggest effects on bacterial fitness in stressful environments. Here we show that PTs are d...

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Bibliografiset tiedot
Julkaisussa:Nat Chem Biol
Päätekijät: Kellner, Stefanie, DeMott, Michael S., Cheng, Ching Pin, Russell, Brandon, Cao, Bo, You, Delin, Dedon, Peter C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577368/
https://ncbi.nlm.nih.gov/pubmed/28604692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2407
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