Inhibition of an NAD(+) Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells

The tumorigenic potential of human pluripotent stem cells (hPSCs) is a major limitation to the widespread use of hPSC derivatives in the clinic. Here, we demonstrate that the small molecule STF-31 is effective at eliminating undifferentiated hPSCs across a broad range of cell culture conditions with...

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Bibliografiset tiedot
Julkaisussa:Stem Cells Transl Med
Päätekijät: Kropp, Erin M., Oleson, Bryndon J., Broniowska, Katarzyna A., Bhattacharya, Subarna, Chadwick, Alexandra C., Diers, Anne R., Hu, Qinghui, Sahoo, Daisy, Hogg, Neil, Boheler, Kenneth R., Corbett, John A., Gundry, Rebekah L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: AlphaMed Press 2015
Aiheet:
Enabling Technologies for Cell-Based Clinical Translation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414215/
https://ncbi.nlm.nih.gov/pubmed/25834119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2014-0163
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