Safety and biodistribution of (111)In-amatuximab in patients with mesothelin expressing cancers using Single Photon Emission Computed Tomography-Computed Tomography (SPECT-CT) imaging

Amatuximab is a chimeric high-affinity monoclonal IgG1/k antibody targeting mesothelin that is being developed for treatment of mesothelin-expressing cancers. Considering the ongoing clinical development of amatuximab in these cancers, our objective was to characterize the biodistribution, and dosim...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Lindenberg, Liza, Thomas, Anish, Adler, Stephen, Mena, Esther, Kurdziel, Karen, Maltzman, Julia, Wallin, Bruce, Hoffman, Kimberly, Pastan, Ira, Paik, Chang Hum, Choyke, Peter, Hassan, Raffit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
Soggetti:
Clinical Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414206/
https://ncbi.nlm.nih.gov/pubmed/25756664
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