IL-32θ inhibits monocytic differentiation of leukemia cells by attenuating expression of transcription factor PU.1

PU.1 is a key transcription factor regulating the myeloid differentiation. PU.1-induced monocytic differentiation into macrophage is also important for blood cancer development. Therefore, we chose THP-1 monocytic leukemia cells to investigate the function of a recently discovered IL-32θ. Genetic an...

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Vydáno v:Oncotarget
Hlavní autoři: Kim, Man Sub, Kang, Jeong-Woo, Park, Yun Sun, Lee, Dong Hun, Bak, Yesol, Kwon, Taeho, Yoon, Do-Young
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414198/
https://ncbi.nlm.nih.gov/pubmed/25726525
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