PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation

Prostate cancer is the leading cancer in North American men. Current pharmacological treatments are limited to anti-androgen strategies and the development of new therapeutic approaches remains a challenge. As a fundamentally new approach, we propose the inhibition of PACE4, a member of the proprote...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Levesque, Christine, Couture, Frédéric, Kwiatkowska, Anna, Desjardins, Roxane, Guérin, Brigitte, Neugebauer, Witold A., Day, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414146/
https://ncbi.nlm.nih.gov/pubmed/25682874
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