PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation

Prostate cancer is the leading cancer in North American men. Current pharmacological treatments are limited to anti-androgen strategies and the development of new therapeutic approaches remains a challenge. As a fundamentally new approach, we propose the inhibition of PACE4, a member of the proprote...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Levesque, Christine, Couture, Frédéric, Kwiatkowska, Anna, Desjardins, Roxane, Guérin, Brigitte, Neugebauer, Witold A., Day, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414146/
https://ncbi.nlm.nih.gov/pubmed/25682874
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