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Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle

Cisplatin is a cytotoxic drug used as a first-line therapy for a wide variety of cancers. However, significant renal and neurological toxicities limits it clinical use. It has been documented that drug toxicities can be mitigated through nanoparticle formulation, while simultaneously increasing tumo...

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Podrobná bibliografie
Vydáno v:J Control Release
Hlavní autoři: Kai, Marc P., Keeler, Amanda W., Perry, Jillian L., Reuter, Kevin G., Luft, J. Christopher, O’Neal, Sara K., Zamboni, William C., DeSimone, Joseph M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413935/
https://ncbi.nlm.nih.gov/pubmed/25744827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.03.001
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