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Targeted PRINT Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation

In this Letter, we varied targeting ligand density of an EGFR binding affibody on the surface of two different hydrogel PRINT nanoparticles (80 nm × 320 and 55 nm × 60 nm) and monitored effects on target-cell association, off-target phagocytic uptake, biodistribution, and tumor accumulation. Interes...

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Detalhes bibliográficos
Publicado no:Nano Lett
Main Authors: Reuter, Kevin G., Perry, Jillian L., Kim, Dongwook, Luft, J. Christopher, Liu, Rihe, DeSimone, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772408/
https://ncbi.nlm.nih.gov/pubmed/26389971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b01362
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