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Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: An in vitro study

OBJECTIVE: Drug toxicity is a hurdle to drug development and to clinical translation of basic research. Antiepileptic drugs such as carbamazepine (CBZ) and selective serotonin reuptake inhibitors such as sertraline (SRT) are commonly co-prescribed to patients with epilepsy and comorbid depression. B...

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Detalhes bibliográficos
Publicado no:Epilepsia
Principais autores: Ghosh, Chaitali, Hossain, Mohammad, Spriggs, Addison, Ghosh, Arnab, Grant, Gerald A., Marchi, Nicola, Perucca, Emilio, Janigro, Damir
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413932/
https://ncbi.nlm.nih.gov/pubmed/25656284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12923
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