NAD(P)H-Independent Asymmetric C=C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates as the Hydrogen Donor

To develop a nicotinamide-independent single flavoenzyme system for the asymmetric bioreduction of C=C bonds, four types of hydrogen donor, encompassing more than 50 candidates, were investigated. Six highly potent, cheap, and commercially available co-substrates were identified that (under the opti...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Winkler, Christoph K, Clay, Dorina, Entner, Marcello, Plank, Markus, Faber, Kurt
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413776/
https://ncbi.nlm.nih.gov/pubmed/24382795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201303897
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