Nitrile as Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases

Asymmetric bioreduction of an (E)-β-cyano-2,4-dienoic acid derivative by ene-reductases allowed a shortened access to a precursor of pregabalin [(S)-3-(aminomethyl)-5-methylhexanoic acid] possessing the desired configuration in up to 94% conversion and >99% ee. Deuterium labelling studies showed...

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Publicat a:Adv Synth Catal
Autors principals: Winkler, Christoph K, Clay, Dorina, Turrini, Nikolaus G, Lechner, Horst, Kroutil, Wolfgang, Davies, Simon, Debarge, Sebastien, O'Neill, Pat, Steflik, Jeremy, Karmilowicz, Mike, Wong, John W, Faber, Kurt
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498475/
https://ncbi.nlm.nih.gov/pubmed/26190962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.201301055
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