Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation

Statins, such as lovastatin, can induce a cell cycle arrest in the G1 phase. This robust antiproliferative activity remains intact in many cancer cells that are deficient in cell cycle checkpoints and leads to an increased expression of CDK inhibitor proteins p27(Kip1) and p21(Cip1). The molecular d...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vosper, Jonathan, Masuccio, Alessia, Kullmann, Michael, Ploner, Christian, Geley, Stephan, Hengst, Ludger
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413625/
https://ncbi.nlm.nih.gov/pubmed/25605247
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