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Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate

Mevalonate kinase (MVK) mutations were previously identified in disseminated superficial actinic porokeratosis. However, the role of MVK in differentiation, apoptosis and prenylation of keratinocytes requires further investigation. Farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP)...

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Bibliografiske detaljer
Udgivet i:Exp Ther Med
Main Authors: Li, Min, Min, Wei, Wang, Jianbo, Wang, Lu, Li, Yan, Zhou, Naihui, Yang, Ziliang, Qian, Qihong
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086283/
https://ncbi.nlm.nih.gov/pubmed/32256770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2020.8569
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