A modular toolkit to inhibit proline-rich motif–mediated protein–protein interactions

Small-molecule competitors of protein–protein interactions are urgently needed for functional analysis of large-scale genomics and proteomics data. Particularly abundant, yet so far undruggable, targets include domains specialized in recognizing proline-rich segments, including Src-homology 3 (SH3),...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Opitz, Robert, Müller, Matthias, Reuter, Cédric, Barone, Matthias, Soicke, Arne, Roske, Yvette, Piotukh, Kirill, Huy, Peter, Beerbaum, Monika, Wiesner, Burkhard, Beyermann, Michael, Schmieder, Peter, Freund, Christian, Volkmer, Rudolf, Oschkinat, Hartmut, Schmalz, Hans-Günther, Kühne, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413326/
https://ncbi.nlm.nih.gov/pubmed/25848013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422054112
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