Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Battling metastasis through inhibition of cell motility is considered a promising approach to support cancer therapies. In this context, Ena/VASP-depending signaling pathways, in particular interactions with their EVH1 domains, are promising targets for pharmaceutical intervention. However, protein–...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Barone, Matthias, Müller, Matthias, Chiha, Slim, Ren, Jiang, Albat, Dominik, Soicke, Arne, Dohmen, Stephan, Klein, Marco, Bruns, Judith, van Dinther, Maarten, Opitz, Robert, Lindemann, Peter, Beerbaum, Monika, Motzny, Kathrin, Roske, Yvette, Schmieder, Peter, Volkmer, Rudolf, Nazaré, Marc, Heinemann, Udo, Oschkinat, Hartmut, ten Dijke, Peter, Schmalz, Hans-Günther, Kühne, Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703624/
https://ncbi.nlm.nih.gov/pubmed/33184177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007213117
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