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Structure of the Get3 targeting factor in complex with its membrane protein cargo

Tail-anchored (TA) proteins are a physiologically important class of membrane proteins targeted to the endoplasmic reticulum by the conserved GET pathway. During transit, their hydrophobic transmembrane domains (TMDs) are chaperoned by the cytosolic targeting factor Get3, but the molecular nature of...

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Publicado en:Science
Autores principales: Mateja, Agnieszka, Paduch, Marcin, Chang, Hsin-Yang, Szydlowska, Anna, Kossiakoff, Anthony A., Hegde, Ramanujan S., Keenan, Robert J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413028/
https://ncbi.nlm.nih.gov/pubmed/25745174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1261671
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