Involvement of Histidine Residue His382 in pH Regulation of MCT4 Activity

Monocarboxylate transporter 4 (MCT4) is a pH-dependent bi-directional lactate transporter. Transport of lactate via MCT4 is increased by extracellular acidification. We investigated the critical histidine residue involved in pH regulation of MCT4 function. Transport of lactate via MCT4 was measured...

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Bibliographic Details
Published in:PLoS One
Main Authors: Sasaki, Shotaro, Kobayashi, Masaki, Futagi, Yuya, Ogura, Jiro, Yamaguchi, Hiroaki, Iseki, Ken
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412719/
https://ncbi.nlm.nih.gov/pubmed/25919709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122738
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