siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8(+) T cells in NOD/SCID/IL2Rg(null) mice

Allogeneic stem cell transplantation (allo-SCT) can be a curative therapy for patients suffering from hematological malignancies. The therapeutic efficacy is based on donor-derived CD8(+) T cells that recognize minor histocompatibility antigens (MiHAs) expressed by patient’s tumor cells. However, th...

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Publicat a:Cancer Immunol Immunother
Autors principals: van der Waart, Anniek B., Fredrix, Hanny, van der Voort, Robbert, Schaap, Nicolaas, Hobo, Willemijn, Dolstra, Harry
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412509/
https://ncbi.nlm.nih.gov/pubmed/25724840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-015-1668-6
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