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The Protein Quality Control Machinery Regulates Its Misassembled Proteasome Subunits
Cellular toxicity introduced by protein misfolding threatens cell fitness and viability. Failure to eliminate these polypeptides is associated with various aggregation diseases. In eukaryotes, the ubiquitin proteasome system (UPS) plays a vital role in protein quality control (PQC), by selectively t...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4412499/ https://ncbi.nlm.nih.gov/pubmed/25919710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005178 |
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