The Protein Quality Control Machinery Regulates Its Misassembled Proteasome Subunits

Cellular toxicity introduced by protein misfolding threatens cell fitness and viability. Failure to eliminate these polypeptides is associated with various aggregation diseases. In eukaryotes, the ubiquitin proteasome system (UPS) plays a vital role in protein quality control (PQC), by selectively t...

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Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Peters, Lee Zeev, Karmon, Ofri, David-Kadoch, Galit, Hazan, Rotem, Yu, Tzenlin, Glickman, Michael H., Ben-Aroya, Shay
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412499/
https://ncbi.nlm.nih.gov/pubmed/25919710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005178
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