The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue

Netrin-1 is a guidance cue that can trigger either attraction or repulsion effects on migrating neurons, depending on the repertoire of receptors available on the growth cone. How a single chemotropic molecule can act in such contradictory ways has long been a puzzle at the molecular level. Here we...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Finci, Lorenzo I., Krüger, Nina, Sun, Xiaqin, Zhang, Jie, Chegkazi, Magda, Wu, Yu, Schenk, Gundolf, Mertens, Haydyn D. T., Svergun, Dmitri I., Zhang, Yan, Wang, Jia-huai, Meijers, Rob
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412161/
https://ncbi.nlm.nih.gov/pubmed/25123307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.07.010
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