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Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon

ABSTRACT: The RAG1 and RAG2 proteins are essential subunits of the V(D)J recombinase that is required for the generation of the enormous variability of antibodies and T-cell receptors in jawed vertebrates. It was demonstrated previously that the 600-aa catalytic core of RAG1 evolved from the transpo...

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Bibliografski detalji
Izdano u:Biol Direct
Glavni autori: Kapitonov, Vladimir V, Koonin, Eugene V
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411706/
https://ncbi.nlm.nih.gov/pubmed/25928409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13062-015-0055-8
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