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ISC, a Novel Group of Bacterial and Archaeal DNA Transposons That Encode Cas9 Homologs

Bacterial genomes encode numerous homologs of Cas9, the effector protein of the type II CRISPR-Cas systems. The homology region includes the arginine-rich helix and the HNH nuclease domain that is inserted into the RuvC-like nuclease domain. These genes, however, are not linked to cas genes or CRISP...

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Bibliografiske detaljer
Udgivet i:J Bacteriol
Main Authors: Kapitonov, Vladimir V., Makarova, Kira S., Koonin, Eugene V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810608/
https://ncbi.nlm.nih.gov/pubmed/26712934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00783-15
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