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APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages

The extent, regulation and enzymatic basis of RNA editing by cytidine deamination are incompletely understood. Here we show that transcripts of hundreds of genes undergo site-specific C>U RNA editing in macrophages during M1 polarization and in monocytes in response to hypoxia and interferons. Th...

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Foilsithe in:Nat Commun
Main Authors: Sharma, Shraddha, Patnaik, Santosh K., Thomas Taggart, R., Kannisto, Eric D., Enriquez, Sally M., Gollnick, Paul, Baysal, Bora E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Pub. Group 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411297/
https://ncbi.nlm.nih.gov/pubmed/25898173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7881
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