Suppression of Human T Cell Proliferation Mediated by the Cathepsin B Inhibitor, z-FA-FMK Is Due to Oxidative Stress

The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-fluoromethyl ketone (z-FA-FMK) readily inhibits anti-CD3-induced human T cell proliferation, whereas the analogue benzyloxycarbonyl-phenylalanine-alanine-diazomethyl ketone (z-FA-DMK) had no effect. In contrast, benzyloxycarbonyl-phe...

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Bibliographic Details
Published in:PLoS One
Main Authors: Rajah, Tanuja, Chow, Sek Chuen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411069/
https://ncbi.nlm.nih.gov/pubmed/25915766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123711
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