Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk.

BACKGROUND: Upon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to apoptosis. In the presence of zVAD-fmk, a broad-spectrum caspase inhibitor, Fas engagement can also trigger an alternative, non-apoptotic caspase-independent form of cell death, which is ini...

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Hauptverfasser: Elodie Lafont, Delphine Milhas, Justin Teissié, Nicole Therville, Nathalie Andrieu-Abadie, Thierry Levade, Hervé Benoist, Bruno Ségui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2010-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC2964310?pdf=render
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