Genetic Polymorphisms of Dihydropyrimidinase in a Japanese Patient with Capecitabine-Induced Toxicity

Dihydropyrimidinase (DHP) is the second enzyme in the catabolic pathway of uracil, thymine, and chemotherapeutic fluoropyrimidine agents such as 5-fluorouracil (5-FU). Thus, DHP deficiency might be associated with 5-FU toxicity during fluoropyrimidine chemotherapy. We performed genetic analyses of t...

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Publicat a:PLoS One
Autors principals: Hiratsuka, Masahiro, Yamashita, Hiroshi, Akai, Fumika, Hosono, Hiroki, Hishinuma, Eiji, Hirasawa, Noriyasu, Mori, Takahiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411063/
https://ncbi.nlm.nih.gov/pubmed/25915935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124818
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