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Single-molecule chemo-mechanical unfolding reveals multiple transition state barriers in a small single-domain protein
A fundamental question in protein folding is whether proteins fold through one or multiple trajectories. While most experiments indicate a single pathway, simulations suggest proteins can fold through many parallel pathways. Here, we use a combination of chemical denaturant, mechanical force and sit...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Pub. Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4410640/ https://ncbi.nlm.nih.gov/pubmed/25882479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7861 |
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