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Direct observation of a force-induced switch in the anisotropic mechanical unfolding pathway of a protein

Many biological processes generate force, and proteins have evolved to resist and respond to tension along different force axes. Single-molecule force spectroscopy allows for molecular insight into the behavior of proteins under force and the mechanism of protein folding in general. Here, we have us...

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Detalhes bibliográficos
Main Authors: Jagannathan, Bharat, Elms, Phillip J., Bustamante, Carlos, Marqusee, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497811/
https://ncbi.nlm.nih.gov/pubmed/22949695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201800109
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